Legacy Drug-Prescribing Patterns in Primary Care.
Identifieur interne : 000796 ( Main/Exploration ); précédent : 000795; suivant : 000797Legacy Drug-Prescribing Patterns in Primary Care.
Auteurs : Dee Mangin [Canada, Nouvelle-Zélande] ; Jennifer Lawson [Canada] ; Jessica Cuppage [Canada] ; Elizabeth Shaw [Canada] ; Katalin Ivanyi [Canada] ; Amie Davis [Canada] ; Cathy Risdon [Canada]Source :
- Annals of family medicine [ 1544-1717 ] ; 2018.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Agents de maintien de la densité osseuse (usage thérapeutique), Antidépresseurs (usage thérapeutique), Diphosphonates (usage thérapeutique), Femelle (MeSH), Humains (MeSH), Inhibiteurs de la pompe à protons (usage thérapeutique), Jeune adulte (MeSH), Mâle (MeSH), Ontario (épidémiologie), Ordonnances médicamenteuses (statistiques et données numériques), Polypharmacie (MeSH), Prescription inappropriée (statistiques et données numériques), Prévalence (MeSH), Soins de santé primaires (statistiques et données numériques), Sujet âgé (MeSH), Types de pratiques des médecins (statistiques et données numériques), Études prospectives (MeSH), Études rétrospectives (MeSH).
- MESH :
- statistiques et données numériques : Ordonnances médicamenteuses, Prescription inappropriée, Soins de santé primaires, Types de pratiques des médecins.
- usage thérapeutique : Agents de maintien de la densité osseuse, Antidépresseurs, Diphosphonates, Inhibiteurs de la pompe à protons.
- épidémiologie : Ontario.
- Adolescent, Adulte, Adulte d'âge moyen, Femelle, Humains, Jeune adulte, Mâle, Polypharmacie, Prévalence, Sujet âgé, Études prospectives, Études rétrospectives.
English descriptors
- KwdEn :
- Adolescent (MeSH), Adult (MeSH), Aged (MeSH), Antidepressive Agents (therapeutic use), Bone Density Conservation Agents (therapeutic use), Diphosphonates (therapeutic use), Drug Prescriptions (statistics & numerical data), Female (MeSH), Humans (MeSH), Inappropriate Prescribing (statistics & numerical data), Male (MeSH), Middle Aged (MeSH), Ontario (epidemiology), Polypharmacy (MeSH), Practice Patterns, Physicians' (statistics & numerical data), Prevalence (MeSH), Primary Health Care (statistics & numerical data), Prospective Studies (MeSH), Proton Pump Inhibitors (therapeutic use), Retrospective Studies (MeSH), Young Adult (MeSH).
- MESH :
- chemical , therapeutic use : Antidepressive Agents, Bone Density Conservation Agents, Diphosphonates, Proton Pump Inhibitors.
- geographic , epidemiology : Ontario.
- statistics & numerical data : Drug Prescriptions, Inappropriate Prescribing, Practice Patterns, Physicians', Primary Health Care.
- Adolescent, Adult, Aged, Female, Humans, Male, Middle Aged, Polypharmacy, Prevalence, Prospective Studies, Retrospective Studies, Young Adult.
Abstract
PURPOSE
Polypharmacy is a key clinical challenge for primary care. Drugs that should be prescribed for an intermediate term (longer than 3 months, but not indefinitely) that are not appropriately discontinued could contribute to polypharmacy. We named this type of prescribing
METHODS
We conducted a population-based retrospective cohort study using prospectively collected data from the McMaster University Sentinel and Information Collaboration (MUSIC) Primary Care Practice Based Research Network, located in Hamilton, Ontario. All adult patients (aged 18 or older) in the MUSIC data set during 2010-2016 were included (N = 50,813). We calculated rates of legacy prescribing of antidepressants (prescription longer than 15 months), bisphosphonates (longer than 5.5 years), and PPIs (longer than 15 months).
RESULTS
The proportion of patients having a legacy prescription at some time during the study period was 46% (3,766 of 8,119) for antidepressants, 14% (228 of 1,592) for bisphosphonates, and 45% (2,885 of 6,414) for PPIs. Many of these patients held current prescriptions. The mean duration of prescribing for all legacy prescriptions was significantly longer than that for non-legacy prescriptions (
CONCLUSIONS
The phenomenon of legacy prescribing appears prevalent. These data demonstrate the potential of legacy prescribing to contribute to unnecessary polypharmacy, providing an opportunity for system-level intervention in primary care with enormous potential benefit for patients.
DOI: 10.1370/afm.2315
PubMed: 30420366
PubMed Central: PMC6231929
Affiliations:
- Canada, Nouvelle-Zélande
- Ontario
- Hamilton (Ontario), Toronto
- Université McMaster, Université de Toronto
Links toward previous steps (curation, corpus...)
Le document en format XML
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type="wicri:Area/Main/Exploration">000657</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Legacy Drug-Prescribing Patterns in Primary Care.</title><author><name sortKey="Mangin, Dee" sort="Mangin, Dee" uniqKey="Mangin D" first="Dee" last="Mangin">Dee Mangin</name><affiliation wicri:level="4"><nlm:affiliation>Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada mangind@mcmaster.ca.</nlm:affiliation><country wicri:rule="url">Canada</country><wicri:regionArea>Department of Family Medicine, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>University of Otago, Christchurch, New Zealand.</nlm:affiliation><country xml:lang="fr">Nouvelle-Zélande</country><wicri:regionArea>University of Otago, Christchurch</wicri:regionArea><wicri:noRegion>Christchurch</wicri:noRegion></affiliation></author><author><name sortKey="Lawson, Jennifer" sort="Lawson, Jennifer" uniqKey="Lawson J" first="Jennifer" last="Lawson">Jennifer Lawson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Family Medicine, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Cuppage, Jessica" sort="Cuppage, Jessica" uniqKey="Cuppage J" first="Jessica" last="Cuppage">Jessica Cuppage</name><affiliation wicri:level="4"><nlm:affiliation>University of Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Shaw, Elizabeth" sort="Shaw, Elizabeth" uniqKey="Shaw E" first="Elizabeth" last="Shaw">Elizabeth Shaw</name><affiliation wicri:level="4"><nlm:affiliation>Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Family Medicine, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Ivanyi, Katalin" sort="Ivanyi, Katalin" uniqKey="Ivanyi K" first="Katalin" last="Ivanyi">Katalin Ivanyi</name><affiliation wicri:level="4"><nlm:affiliation>Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Family Medicine, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Stonechurch Family Health Centre, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Stonechurch Family Health Centre, Hamilton, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Davis, Amie" sort="Davis, Amie" uniqKey="Davis A" first="Amie" last="Davis">Amie Davis</name><affiliation wicri:level="4"><nlm:affiliation>Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Family Medicine, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Halton McMaster Family Health Centre, Burlington, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Halton McMaster Family Health Centre, Burlington, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Risdon, Cathy" sort="Risdon, Cathy" uniqKey="Risdon C" first="Cathy" last="Risdon">Cathy Risdon</name><affiliation wicri:level="4"><nlm:affiliation>Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Family Medicine, McMaster University, Hamilton, Ontario</wicri:regionArea><orgName type="university">Université McMaster</orgName><placeName><settlement type="city">Hamilton (Ontario)</settlement><region type="state">Ontario</region></placeName></affiliation></author></analytic><series><title level="j">Annals of family medicine</title><idno type="eISSN">1544-1717</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Adult (MeSH)</term><term>Aged (MeSH)</term><term>Antidepressive Agents (therapeutic use)</term><term>Bone Density Conservation Agents (therapeutic use)</term><term>Diphosphonates (therapeutic use)</term><term>Drug Prescriptions (statistics & numerical data)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Inappropriate Prescribing (statistics & numerical data)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Ontario (epidemiology)</term><term>Polypharmacy (MeSH)</term><term>Practice Patterns, Physicians' (statistics & numerical data)</term><term>Prevalence (MeSH)</term><term>Primary Health Care (statistics & numerical data)</term><term>Prospective Studies (MeSH)</term><term>Proton Pump Inhibitors (therapeutic use)</term><term>Retrospective Studies (MeSH)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Agents de maintien de la densité osseuse (usage thérapeutique)</term><term>Antidépresseurs (usage thérapeutique)</term><term>Diphosphonates (usage thérapeutique)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Inhibiteurs de la pompe à protons (usage thérapeutique)</term><term>Jeune adulte (MeSH)</term><term>Mâle (MeSH)</term><term>Ontario (épidémiologie)</term><term>Ordonnances médicamenteuses (statistiques et données numériques)</term><term>Polypharmacie (MeSH)</term><term>Prescription inappropriée (statistiques et données numériques)</term><term>Prévalence (MeSH)</term><term>Soins de santé primaires (statistiques et données numériques)</term><term>Sujet âgé (MeSH)</term><term>Types de pratiques des médecins (statistiques et données numériques)</term><term>Études prospectives (MeSH)</term><term>Études rétrospectives (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antidepressive Agents</term><term>Bone Density Conservation Agents</term><term>Diphosphonates</term><term>Proton Pump Inhibitors</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Ontario</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Drug Prescriptions</term><term>Inappropriate Prescribing</term><term>Practice Patterns, Physicians'</term><term>Primary Health Care</term></keywords><keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Ordonnances médicamenteuses</term><term>Prescription inappropriée</term><term>Soins de santé primaires</term><term>Types de pratiques des médecins</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents de maintien de la densité osseuse</term><term>Antidépresseurs</term><term>Diphosphonates</term><term>Inhibiteurs de la pompe à protons</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Ontario</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polypharmacy</term><term>Prevalence</term><term>Prospective Studies</term><term>Retrospective Studies</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Polypharmacie</term><term>Prévalence</term><term>Sujet âgé</term><term>Études prospectives</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>PURPOSE</b></p><p>Polypharmacy is a key clinical challenge for primary care. Drugs that should be prescribed for an intermediate term (longer than 3 months, but not indefinitely) that are not appropriately discontinued could contribute to polypharmacy. We named this type of prescribing </p></div><div type="abstract" xml:lang="en"><p><b>METHODS</b></p><p>We conducted a population-based retrospective cohort study using prospectively collected data from the McMaster University Sentinel and Information Collaboration (MUSIC) Primary Care Practice Based Research Network, located in Hamilton, Ontario. All adult patients (aged 18 or older) in the MUSIC data set during 2010-2016 were included (N = 50,813). We calculated rates of legacy prescribing of antidepressants (prescription longer than 15 months), bisphosphonates (longer than 5.5 years), and PPIs (longer than 15 months).</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>The proportion of patients having a legacy prescription at some time during the study period was 46% (3,766 of 8,119) for antidepressants, 14% (228 of 1,592) for bisphosphonates, and 45% (2,885 of 6,414) for PPIs. Many of these patients held current prescriptions. The mean duration of prescribing for all legacy prescriptions was significantly longer than that for non-legacy prescriptions (</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>The phenomenon of legacy prescribing appears prevalent. These data demonstrate the potential of legacy prescribing to contribute to unnecessary polypharmacy, providing an opportunity for system-level intervention in primary care with enormous potential benefit for patients.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30420366</PMID><DateCompleted><Year>2019</Year><Month>11</Month><Day>05</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1544-1717</ISSN><JournalIssue CitedMedium="Internet"><Volume>16</Volume><Issue>6</Issue><PubDate><Year>2018</Year><Month>11</Month></PubDate></JournalIssue><Title>Annals of family medicine</Title><ISOAbbreviation>Ann Fam Med</ISOAbbreviation></Journal><ArticleTitle>Legacy Drug-Prescribing Patterns in Primary Care.</ArticleTitle><Pagination><MedlinePgn>515-520</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1370/afm.2315</ELocationID><Abstract><AbstractText Label="PURPOSE">Polypharmacy is a key clinical challenge for primary care. Drugs that should be prescribed for an intermediate term (longer than 3 months, but not indefinitely) that are not appropriately discontinued could contribute to polypharmacy. We named this type of prescribing <i>legacy prescribing</i>. Commonly prescribed drugs with legacy prescribing potential include antidepressants, bisphosphonates, and proton pump inhibitors (PPIs). We evaluated the proportion of legacy prescribing within these drug classes.</AbstractText><AbstractText Label="METHODS">We conducted a population-based retrospective cohort study using prospectively collected data from the McMaster University Sentinel and Information Collaboration (MUSIC) Primary Care Practice Based Research Network, located in Hamilton, Ontario. All adult patients (aged 18 or older) in the MUSIC data set during 2010-2016 were included (N = 50,813). We calculated rates of legacy prescribing of antidepressants (prescription longer than 15 months), bisphosphonates (longer than 5.5 years), and PPIs (longer than 15 months).</AbstractText><AbstractText Label="RESULTS">The proportion of patients having a legacy prescription at some time during the study period was 46% (3,766 of 8,119) for antidepressants, 14% (228 of 1,592) for bisphosphonates, and 45% (2,885 of 6,414) for PPIs. Many of these patients held current prescriptions. The mean duration of prescribing for all legacy prescriptions was significantly longer than that for non-legacy prescriptions (<i>P</i> <.001). Concurrent legacy prescriptions for both antidepressants and PPIs was common, signaling a potential prescribing cascade.</AbstractText><AbstractText Label="CONCLUSIONS">The phenomenon of legacy prescribing appears prevalent. These data demonstrate the potential of legacy prescribing to contribute to unnecessary polypharmacy, providing an opportunity for system-level intervention in primary care with enormous potential benefit for patients.</AbstractText><CopyrightInformation>© 2018 Annals of Family Medicine, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mangin</LastName><ForeName>Dee</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada mangind@mcmaster.ca.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>University of Otago, Christchurch, New Zealand.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lawson</LastName><ForeName>Jennifer</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cuppage</LastName><ForeName>Jessica</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>University of Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shaw</LastName><ForeName>Elizabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ivanyi</LastName><ForeName>Katalin</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Stonechurch Family Health Centre, Hamilton, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Davis</LastName><ForeName>Amie</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Halton McMaster Family Health Centre, Burlington, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Risdon</LastName><ForeName>Cathy</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Family Medicine, McMaster University, Hamilton, Ontario, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D023362">Evaluation Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Ann Fam Med</MedlineTA><NlmUniqueID>101167762</NlmUniqueID><ISSNLinking>1544-1709</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000928">Antidepressive Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D050071">Bone Density Conservation Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004164">Diphosphonates</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D054328">Proton Pump Inhibitors</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000928" MajorTopicYN="N">Antidepressive Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050071" MajorTopicYN="N">Bone Density Conservation Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004164" MajorTopicYN="N">Diphosphonates</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011307" MajorTopicYN="N">Drug Prescriptions</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057970" MajorTopicYN="N">Inappropriate Prescribing</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical 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PubStatus="medline"><Year>2019</Year><Month>11</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30420366</ArticleId><ArticleId IdType="pii">16/6/515</ArticleId><ArticleId IdType="doi">10.1370/afm.2315</ArticleId><ArticleId IdType="pmc">PMC6231929</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Am Geriatr Soc. 2015 Nov;63(11):2227-46</Citation><ArticleIdList><ArticleId IdType="pubmed">26446832</ArticleId></ArticleIdList></Reference><Reference><Citation>Can J Psychiatry. 2016 Sep;61(9):540-60</Citation><ArticleIdList><ArticleId IdType="pubmed">27486148</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Geriatr Pharmacother. 2008 Dec;6(5):249-54</Citation><ArticleIdList><ArticleId IdType="pubmed">19161927</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Clin Pharmacol. 2009 Jun;67(6):624-8</Citation><ArticleIdList><ArticleId IdType="pubmed">19594530</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2004 Dec 30;351(27):2870-4</Citation><ArticleIdList><ArticleId IdType="pubmed">15625341</ArticleId></ArticleIdList></Reference><Reference><Citation>BMJ Qual Saf. 2015 Feb;24(2):167-74</Citation><ArticleIdList><ArticleId IdType="pubmed">25552584</ArticleId></ArticleIdList></Reference><Reference><Citation>J Clin Psychiatry. 2014 Mar;75(3):205-14</Citation><ArticleIdList><ArticleId IdType="pubmed">24717376</ArticleId></ArticleIdList></Reference><Reference><Citation>Cochrane Database Syst Rev. 2017 Mar 16;3:CD011969</Citation><ArticleIdList><ArticleId IdType="pubmed">28301676</ArticleId></ArticleIdList></Reference><Reference><Citation>Can J Clin Pharmacol. 2007 Fall;14(3):e283-90</Citation><ArticleIdList><ArticleId IdType="pubmed">18025543</ArticleId></ArticleIdList></Reference><Reference><Citation>Eur J Gen Pract. 2010 Jun;16(2):106-12</Citation><ArticleIdList><ArticleId IdType="pubmed">20297924</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Geriatr. 2015 Mar 25;15:31</Citation><ArticleIdList><ArticleId IdType="pubmed">25879993</ArticleId></ArticleIdList></Reference><Reference><Citation>J Gerontol Nurs. 2005 Sep;31(9):4-11</Citation><ArticleIdList><ArticleId IdType="pubmed">16190007</ArticleId></ArticleIdList></Reference><Reference><Citation>Fam Pract. 2013 Jun;30(3):313-9</Citation><ArticleIdList><ArticleId IdType="pubmed">23132894</ArticleId></ArticleIdList></Reference><Reference><Citation>CMAJ. 2004 May 25;170(11):1678-86</Citation><ArticleIdList><ArticleId IdType="pubmed">15159366</ArticleId></ArticleIdList></Reference><Reference><Citation>Med Clin North Am. 2015 Mar;99(2):295-310</Citation><ArticleIdList><ArticleId IdType="pubmed">25700585</ArticleId></ArticleIdList></Reference><Reference><Citation>J Bone Miner Res. 2012 Feb;27(2):243-54</Citation><ArticleIdList><ArticleId IdType="pubmed">22161728</ArticleId></ArticleIdList></Reference><Reference><Citation>BMC Med. 2018 Jun 13;16(1):91</Citation><ArticleIdList><ArticleId IdType="pubmed">29895310</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Glob Health. 2013 Oct;1(4):e182-3</Citation><ArticleIdList><ArticleId IdType="pubmed">25104342</ArticleId></ArticleIdList></Reference><Reference><Citation>Drugs Aging. 2018 Jul;35(7):575-587</Citation><ArticleIdList><ArticleId IdType="pubmed">30006810</ArticleId></ArticleIdList></Reference><Reference><Citation>BMJ. 2012 Jun 13;344:e3526</Citation><ArticleIdList><ArticleId IdType="pubmed">22695898</ArticleId></ArticleIdList></Reference><Reference><Citation>Fam Pract. 2008 Dec;25 Suppl 1:i20-4</Citation><ArticleIdList><ArticleId IdType="pubmed">18794201</ArticleId></ArticleIdList></Reference><Reference><Citation>J Am Geriatr Soc. 2016 May;64(5):1079-84</Citation><ArticleIdList><ArticleId IdType="pubmed">27130965</ArticleId></ArticleIdList></Reference><Reference><Citation>J Am Board Fam Med. 2011 Nov-Dec;24(6):717-27</Citation><ArticleIdList><ArticleId IdType="pubmed">22086815</ArticleId></ArticleIdList></Reference><Reference><Citation>Pharmacoepidemiol Drug Saf. 2017 Oct;26(10):1242-1247</Citation><ArticleIdList><ArticleId IdType="pubmed">28799295</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2017 May 6;389(10081):1778-1780</Citation><ArticleIdList><ArticleId IdType="pubmed">28495154</ArticleId></ArticleIdList></Reference><Reference><Citation>Epilepsia. 2017 Nov;58(11):2002-2009</Citation><ArticleIdList><ArticleId IdType="pubmed">28944447</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Gen Pract. 2011 Jan;61(582):e12-21</Citation><ArticleIdList><ArticleId IdType="pubmed">21401985</ArticleId></ArticleIdList></Reference><Reference><Citation>Acta Psychiatr Scand Suppl. 2004;(420):47-54</Citation><ArticleIdList><ArticleId IdType="pubmed">15128387</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet. 2003 Feb 22;361(9358):653-61</Citation><ArticleIdList><ArticleId IdType="pubmed">12606176</ArticleId></ArticleIdList></Reference><Reference><Citation>BMJ. 2009 Aug 11;339:b2803</Citation><ArticleIdList><ArticleId IdType="pubmed">19671932</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Psychiatry. 2001 Feb;178:145-53</Citation><ArticleIdList><ArticleId IdType="pubmed">11157427</ArticleId></ArticleIdList></Reference><Reference><Citation>Med J Aust. 1999 Feb 15;170(4):171-3</Citation><ArticleIdList><ArticleId IdType="pubmed">10078183</ArticleId></ArticleIdList></Reference><Reference><Citation>BMJ. 2000 Mar 18;320(7237):771-3</Citation><ArticleIdList><ArticleId IdType="pubmed">10720364</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2005 Aug 10;294(6):716-24</Citation><ArticleIdList><ArticleId IdType="pubmed">16091574</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA Intern Med. 2014 Jan;174(1):8-9</Citation><ArticleIdList><ArticleId IdType="pubmed">24080955</ArticleId></ArticleIdList></Reference><Reference><Citation>J Fam Pract. 2000 Dec;49(12):1113-20</Citation><ArticleIdList><ArticleId IdType="pubmed">11132061</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Psychol Rev. 2007 Dec;27(8):959-85</Citation><ArticleIdList><ArticleId IdType="pubmed">17448579</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2006 Dec 27;296(24):2927-38</Citation><ArticleIdList><ArticleId IdType="pubmed">17190893</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Pharmacol Ther. 2009 Jan;85(1):86-8</Citation><ArticleIdList><ArticleId 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